当前位置：首页>产品中心>单抗/多抗>Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody|抗呼肠孤病毒外层衣壳蛋白σ-1多克隆抗体(靶标：呼肠孤病毒外层衣壳蛋白σ1)
Anti-Reovirus Outer capsid protein sigma-1 Polyclonal Antibody|抗呼肠孤病毒外层衣壳蛋白σ-1多克隆抗体(靶标：呼肠孤病毒外层衣壳蛋白σ1)
- 货号：RB9TVK138014
- 价格：面议
- 点击：447
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Reovirus type 1 |
| 靶标 | Cell attachment protein, Hemagglutinin, Outer capsid protein sigma-1, S1, Sigma1 |
| 免疫原 | E. coli - derived recombinant Reovirus Outer capsid protein sigma-1 (Val258-Arg470). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P04506 |
| 背景信息 | Outer capsid protein sigma-1 is a ~51 kDa protein. Fiber-like molecule that attaches the virion to the host cell membrane by binding with initial low affinity to sialic acid containing proteins, followed by high-affinity bindingto the entry receptor F11R/JAM-A. Also binds to the ganglioside GM2 as an alternate receptor, this binding is serotype-specific. The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. 1. Reiss, K. et al. (2012) PLoS pathogens 8, e1003078. PMID: 23236285 |
| 备注 | For research use only |
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