Anti-Human MAPK10 Polyclonal Antibody|抗人MAPK10多克隆抗体(靶标：人丝裂原活化蛋白激酶10/JNK3)
- 货号：RB9THX886014
- 价格：面议
- 点击：265
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Rat, Human |
| 靶标 | EC:2.7.11.24, JNK3, JNK3A, MAP kinase 10, MAP kinase p49 3F12, MAPK 10, MAPK10, Mitogen-activated protein kinase 10, PRKM10, SAPK1B, SAPK1b, Stress-activated protein kinase 1b, Stress-activated protei |
| 免疫原 | E. coli - derived recombinant Human MAPK10 (Val30-Asn407). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P53779 |
| 背景信息 | Mitogen-activated protein kinase 10 (MAPK10) is a ~52 kDa protein. Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. 1. Yoshitane, H. et al. (2012) EMBO reports 13, 455-61. PMID: 22441692 2. Huang, J. et al. (2012) Nature 482, 542-6. PMID: 22327296 |
| 备注 | For research use only |
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