Anti-Human WDR24 Polyclonal Antibody|抗人WDR24多克隆抗体(靶标：人WD重复结构域蛋白24)
- 货号：RB9THP377024
- 价格：面议
- 点击：315
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | C16orf21, EC:2.3.2.27, GATOR2 complex protein WDR24, WD repeat-containing protein 24, WDR24 |
| 免疫原 | E. coli - derived recombinant Human WDR24 (Met21-Ala331). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q96S15 |
| 背景信息 | GATOR2 complex protein WDR24 is a ~88 kDa protein. Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. 1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238 2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 3. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 4. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210 5. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 6. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027 7. Dai, X. et al. (2023) Nature metabolism 5, 265-276. PMID: 36732624 |
| 备注 | For research use only |
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