| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | ATP6V0D2, V-ATPase subunit d 2, V-type proton ATPase subunit d 2, Vacuolar proton pump subunit d 2 |
| 免疫原 | E. coli - derived recombinant Mouse ATP6V0D2 (Met1-Leu350). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q80SY3 |
| 背景信息 | V-type proton ATPase subunit d 2 (ATP6V0D2) is a ~40 kDa protein. Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation. 1. Nishi, T. et al. (2003) The Journal of biological chemistry 278, 46396-402. PMID: 12963731 2. Lee, SH. et al. (2006) Nature medicine 12, 1403-9. PMID: 17128270 |
| 备注 | For research use only |