当前位置：首页>产品中心>单抗/多抗>Anti-Human TSPAN14 Polyclonal Antibody|抗人TSPAN14多克隆抗体(靶标：人四跨膜蛋白14/Tetraspanin-14)
Anti-Human TSPAN14 Polyclonal Antibody|抗人TSPAN14多克隆抗体(靶标：人四跨膜蛋白14/Tetraspanin-14)
- 货号：RB9THD404014
- 价格：面议
- 点击：541
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | DC-TM4F2, TM4SF14, TSPAN14, Tetraspanin-14, Transmembrane 4 superfamily member 14, Tspan-14 |
| 免疫原 | E. coli - derived recombinant Human TSPAN14 (Leu114-Asn232). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q8NG11 |
| 背景信息 | Tetraspanin-14 (TSPAN14) is a ~30 kDa protein. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Negatively regulates ADAM10-mediated cleavage of GP6. Promotes ADAM10-mediated cleavage of CDH5. 1. Haining, EJ. et al. (2012) The Journal of biological chemistry 287, 39753-65. PMID: 23035126 2. Noy, PJ. et al. (2016) The Journal of biological chemistry 291, 3145-57. PMID: 26668317 3. Jouannet, S. et al. (2016) Cellular and molecular life sciences : CMLS 73, 1895-915. PMID: 26686862 4. Lipper, CH. et al. (2023) Cell 186, 3632-3641.e10. PMID: 37516108 |
| 备注 | For research use only |
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