Anti-Human GPR25 Polyclonal Antibody|抗人GPR25多克隆抗体(靶标：人G蛋白偶联受体25)
- 货号：RB9THD143014
- 价格：面议
- 点击：223
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | GPR25, Probable G-protein coupled receptor 25 |
| 免疫原 | E. coli - derived recombinant Human GPR25 (Ala2-Val40&Ala96-Ala127&Val176-Gly201&Leu263-Thr290&Leu310-Trp361). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O00155 |
| 背景信息 | C-X-C chemokine receptor GPR25 is a ~38 kDa protein. Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts. 1. Ocón, B. et al. (2024) Nature 635, 736-745. PMID: 39293486 2. Hu, WF. et al. (2025) The FEBS journal 292, 5998-6015. PMID: 40279398 |
| 备注 | For research use only |
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